Comparison of 18F-AlF-NOTA-FAPI and 18F-FDG Imaging in a Patient With Gastric Signet-Ring Cell Carcinoma

  • Clin Nucl Med. 2021 Nov 1;46(11):929-930. doi: 10.1097/RLU.0000000000003742.
Yue-Hong Guo  1 ,  Min-Fu Yang
Affiliations
  • 1. From the Department of Nuclear Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
PMID: 34606486 DOI: 10.1097/RLU.0000000000003742
Abstract

Several case reports have shown fibroblast activation protein inhibitor (FAPI) imaging to be superior to 18F-FDG imaging in the delineation of primary gastric signet-ring cell carcinoma lesions. In this case, 18F-AlF-NOTA-FAPI PET/CT showed more metastatic lesions that had more increased activity than 18F-FDG PET/CT. However, neither 18F-AlF-NOTA-FAPI nor 18F-FDG imaging revealed any abnormal uptake in the primary gastric lesion, which was subsequently demonstrated to be the primary lesion by pathology.

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