Isolation and biological activity of azocine and azocane alkaloids
- Bioorg Med Chem. 2022 Jan 15;54:116560. doi: 10.1016/j.bmc.2021.116560.
Affiliations
- 1. School of Chemical Sciences, University of Auckland, 23 Symonds Street, Auckland, New Zealand.
- 2. School of Chemical Sciences, University of Auckland, 23 Symonds Street, Auckland, New Zealand. Electronic address: [email protected].
PMID: 34923389
DOI: 10.1016/j.bmc.2021.116560
Abstract
Thousands of known Alkaloids contain a nitrogen (N) heterocycle. While five-, six- and seven-membered N-heterocycles (ie: pyrroles, imidazoles, indoles, pyridines and azepines and their saturated variants) are common, those with an eight-membered N-heterocycle are comparatively rare. This review discusses the structure and bioactivity of Alkaloids that contain an azocine (or saturated azocane) ring, and the array of sources whence they originate.
Keywords
Alkaloid; Azocane; Azocine; Natural product.