Rhodomollosides A and B, glycosides of methyl everninate from the aerial parts of Rhododendron molle

  • J Asian Nat Prod Res. 2022 Nov;24(11):1025-1032. doi: 10.1080/10286020.2021.2011241.
Xue-Rong Yang  1  2 ,  Naonobu Tanaka  2 ,  Jing-Ru Song  1 ,  Feng-Lai Lu  1 ,  Xiao-Jie Yan  1 ,  Jian-Xing Li  3 ,  Xue-Ying Zhao  1  4 ,  Yoshiki Kashiwada  2 ,  Dian-Peng Li  1
Affiliations
  • 1. Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization, Guangxi Institute of Botany, Guangxi Zhuang Autonomous Region, Chinese Academy of Sciences, Guilin 541006, China.
  • 2. Graduate School of Pharmaceutical Sciences, Tokushima University, Tokushima 770-8505, Japan.
  • 3. Guangxi Key Laboratory of Plant Conservation and Restoration Ecology in Karst Terrain, Guangxi Institute of Botany, Guangxi Zhuang Autonomous Region, Chinese Academy of Sciences, Guilin 541006, China.
  • 4. College of life science, Guangxi Normal University, Guilin 5410061, China.
PMID: 34937451 DOI: 10.1080/10286020.2021.2011241
Abstract

Two new glycosides of methyl everninate, rhodomollosides A (1) and B (2), were isolated from the aerial parts of a medicinal plant Rhododendron molle. The structures of 1 and 2 were elucidated on the basis of detailed spectroscopic analyses as well as HPLC analyses for thiazolidine derivatives of their sugar moieties. The sugar moiety of rhodomolloside A (1) was elucidated to be a rare monosaccharide, D-allose, while rhodomolloside B (2) was assigned as a D-glucoside of methyl everninate. Furthermore, they were evaluated for their cytotoxicity against RAW264.7 cells, and for their inhibitory effects with a lipopolysaccharide (LPS)-stimulated murine macrophages RAW 264.7 cells model.

Keywords
D-allose; Eriaceae; Rhododendron molle; glycosides of methyl everninate; rhodomollosides A and B.
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