Thermlanseedlines A-G, seven thermopsine-based alkaloids with antiviral and insecticidal activities from the seeds of Thermopsis lanceolata R. Br

  • Fitoterapia. 2022 Apr:158:105140. doi: 10.1016/j.fitote.2022.105140.
Peng Zhang  1 ,  Qiao An  2 ,  Ping Yi  2 ,  Yue Cui  3 ,  Ji-Bin Zou  2 ,  Chun-Mao Yuan  2 ,  Yu Zhang  4 ,  Wei Gu  2 ,  Lie-Jun Huang  2 ,  Li-Hua Zhao  5 ,  Zhan-Xing Hu  6 ,  Xiao-Jiang Hao  7
Affiliations
  • 1. State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, PR China; The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, PR China; School of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China.
  • 2. State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, PR China; The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, PR China.
  • 3. The Institute of Biotechnology and Germplasm Resources, Yunnan Academy of Agricultural Sciences, Kunming 650204, PR China.
  • 4. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming 650201, PR China.
  • 5. The Institute of Biotechnology and Germplasm Resources, Yunnan Academy of Agricultural Sciences, Kunming 650204, PR China. Electronic address: [email protected].
  • 6. State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, PR China; The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, PR China. Electronic address: [email protected].
  • 7. State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, PR China; The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, PR China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming 650201, PR China. Electronic address: [email protected].
PMID: 35122885 DOI: 10.1016/j.fitote.2022.105140
Abstract

Seven undescribed thermopsine-based Alkaloids (1-7), including one undescribed biogenetically related intermediate (7), were isolated from the seeds of Thermopsis lanceolata R. Br. Compound 1 possessed a 6/6-6 tricyclic skeleton, while compounds 2-6 represented three rare dimerization patterns constructed by Quinolizidine Alkaloids. Their structures were elucidated by comprehensive spectroscopic data analysis as well as ECD calculations. Biologically, compound 6 displayed significant anti-Tomato spotted wilt virus (TSWV) activity compared with the positive control ningnanmycin. Moreover, compound 1 exhibited good insecticidal activity against Aphis fabae with LC50 value of 25.2 mg/L.

Keywords
Anti-TSMV; Insecticidal activity; Quinolizidine alkaloids; Thermopsis lanceolata R. Br..
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