Cuproptosis: Cellular and molecular mechanisms underlying copper-induced cell death

  • Mol Cell. 2022 May 19;82(10):1786-1787. doi: 10.1016/j.molcel.2022.05.001.
Paul A Cobine  1 ,  Donita C Brady  2
Affiliations
  • 1. The Department of Biological Sciences, Auburn University, Auburn, AL 36849, USA. Electronic address: [email protected].
  • 2. Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: [email protected].
PMID: 35594843 DOI: 10.1016/j.molcel.2022.05.001
Abstract

Tsvetkov et al. (2022) discovered a new form of cell death triggered by targeted accumulation of Cu in mitochondria that drives lipoylated TCA cycle enzyme aggregation via direct Cu binding.