Recombinant human interferon-α1b inhibits SARS-CoV-2 better than interferon-α2b in vitro

  • Virol Sin. 2022 Apr;37(2):295-298. doi: 10.1016/j.virs.2022.01.031.
Danrong Shi  1 Keda Chen  2 Xiangyun Lu  1 Linfang Cheng  1 Tianhao Weng  1 Fumin Liu  1 Nanping Wu  3 Lanjuan Li  4 Hangping Yao  5
Affiliations
  • 1. State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.
  • 2. Shulan International Medical College, Zhejiang Shuren University, Hangzhou, 310015, China.
  • 3. State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China. Electronic address: [email protected].
  • 4. State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China. Electronic address: [email protected].
  • 5. State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China. Electronic address: [email protected].
Abstract

  1. A comprehensive evaluation method for anti-SARS-CoV-2 drugs was established based on qPCR, TCID50, and immunofluorescence.

  2. A significant Antiviral effect of rHuIFN-α1b was shown in Vero and Calu-3 ​cells.

  3. rHuIFN-α1b has a good potential in the application of anti-COVID-19 therapy.

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