Clearing the air: Uniquely engaging furin as an approach to cystic fibrosis therapy

  • Cell Chem Biol. 2022 Jun 16;29(6):927-929. doi: 10.1016/j.chembiol.2022.05.011.
Digant Nayak  1 ,  Elizabeth V Wasmuth  1 ,  Shaun K Olsen  2
Affiliations
  • 1. Department of Biochemistry & Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
  • 2. Department of Biochemistry & Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA. Electronic address: [email protected].
PMID: 35714591 DOI: 10.1016/j.chembiol.2022.05.011
Abstract

In this issue of Cell Chemical Biology, Douglas et al. describe a potent, specific, and cell-permeable Furin Inhibitor that interacts with a cryptic binding site to rescue hallmarks of cystic fibrosis in human ex vivo models. BOS-318 holds promise for development of therapeutics targeting an array of furin-dependent pathologies.

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