Alloferon-1 ameliorates acute inflammatory responses in λ-carrageenan-induced paw edema in mice

  • Sci Rep. 2022 Oct 6;12(1):16689. doi: 10.1038/s41598-022-20648-z.
Xiangrui Zhang  1 ,  Vladimir Retyunskiy  1 ,  Shuai Qiao  1 ,  Ye Zhao  2 ,  Chi-Meng Tzeng  3  4  5
Affiliations
  • 1. School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 211800, China.
  • 2. School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 211800, China. [email protected].
  • 3. School of Pharmaceutical Sciences, Xiamen University, Xiamen, 361005, China. [email protected].
  • 4. Translational Medicine Research Center-Key Laboratory for Cancer T-Cell Theragnostic and Clinical Translation, School of Pharmaceutical Sciences, Xiamen University, Xiamen, 361005, China. [email protected].
  • 5. Xiamen Chang Gung Hospital Medical Research Center, Xiamen, 361005, China. [email protected].
PMID: 36202869 DOI: 10.1038/s41598-022-20648-z
Abstract

Alloferon-1 have been proposed as an effective peptide to enhance antitumoral immunity, Antiviral defense and anti-inflammatory activity. This work aimed to assess anti-inflammatory effects of alloferon-1 against acute inflammation and histopathological deformations in λ-carrageenan-induced paw edema in mice. Systemic pretreatment with alloferon-1 (22.0 mg/kg) intraperitoneally injected mice showed a significant reduction in paw thickness and vascular permeability. Alloferon-1 prevented λ-carrageenan-evoked exudation and the neutrophil influx to the mouse pleura and the neutrophil migration into carrageenan-stimulated mouse air pouches based on the histopathological changes in the paw tissues. Administration of alloferon-1 also suppressed the expression of the inflammatory cytokines in the inflamed paw tissues such as tumor necrosis factor-α (TNF-α), monocyte chemoattractant protein 1 (MCP1), interleukin-5 (IL-5), etc. detected by Luminex liquid chip. Collectively, the present study provides evidences for the marked anti-inflammatory effects of alloferon-1 which might represent new therapeutic options for the treatment of acute inflammatory diseases.

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