The stress-inducible ER chaperone GRP78/BiP is upregulated during SARS-CoV-2 infection and acts as a pro-viral protein

  • Nat Commun. 2022 Nov 14;13(1):6551. doi: 10.1038/s41467-022-34065-3.
Woo-Jin Shin  #  1 ,  Dat P Ha  #  2  3 ,  Keigo Machida  4 ,  Amy S Lee  5  6
Affiliations
  • 1. Florida Research and Innovation Center, Cleveland Clinic, Port St. Lucie, FL, 34987, USA.
  • 2. Department of Biochemistry and Molecular Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.
  • 3. Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.
  • 4. Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.
  • 5. Department of Biochemistry and Molecular Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA. [email protected].
  • 6. Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA. [email protected].
  • # Contributed equally.
PMID: 36376289 DOI: 10.1038/s41467-022-34065-3