The enhanced antibacterial effect of BNNS_Van@CS/MAO coating on Mg alloy for orthopedic applications

  • Colloids Surf B Biointerfaces. 2023 Jan:221:112971. doi: 10.1016/j.colsurfb.2022.112971.
Wenjiang Huang  1 ,  Di Mei  2 ,  Yan Zhong  1 ,  Jingan Li  2 ,  Shijie Zhu  3 ,  Yao Chen  2 ,  Liguo Wang  4 ,  Shaokang Guan  5
Affiliations
  • 1. School of Materials Science and Engineering, Zhengzhou University, Zhengzhou 450001, China.
  • 2. School of Materials Science and Engineering, Zhengzhou University, Zhengzhou 450001, China; Henan Key Laboratory of Advanced Magnesium Alloys, Zhengzhou 450002, China.
  • 3. School of Materials Science and Engineering, Zhengzhou University, Zhengzhou 450001, China; Henan Key Laboratory of Advanced Magnesium Alloys, Zhengzhou 450002, China; Key Laboratory of Advanced Materials Processing & Mold Ministry of Education, Zhengzhou 450002, China. Electronic address: [email protected].
  • 4. School of Materials Science and Engineering, Zhengzhou University, Zhengzhou 450001, China; Henan Key Laboratory of Advanced Magnesium Alloys, Zhengzhou 450002, China; Key Laboratory of Advanced Materials Processing & Mold Ministry of Education, Zhengzhou 450002, China. Electronic address: [email protected].
  • 5. School of Materials Science and Engineering, Zhengzhou University, Zhengzhou 450001, China; Henan Key Laboratory of Advanced Magnesium Alloys, Zhengzhou 450002, China; Key Laboratory of Advanced Materials Processing & Mold Ministry of Education, Zhengzhou 450002, China.
PMID: 36395618 DOI: 10.1016/j.colsurfb.2022.112971
Abstract

The development of multifunctional Mg-based active implants with controllable degradation and Antibacterial capabilities has become a hotspot in the research field of biodegradable metallic Materials. To this end, a BN nanosheets (BNNS) _vancomycin (Van) @chitosan (CS) nanocomposite coating containing two Antibacterial components (BNNS and Van) was prepared on Mg alloys via a micro-arc oxidation (MAO) pre-treatment combined with following electrodeposition. The related characterizations of the coating show that the composite coating has a high roughness, hydrophobicity and fair corrosion resistance. In vitro Antibacterial experiments show that the BNNS_Van@CS/MAO composite coating have obvious inhibitory effect on the growth of both E. coli and S. aureus. The Antibacterial effect of the BNNS_Van@CS/MAO composite coating was attributed to the synergistic effect of CS, BNNS and Van. This study provides a valuable surface modification strategy for developing multifunctional Mg-based implants with good corrosion resistance and Antibacterial properties.

Keywords
Biodegradable; Boron nitride nanosheets; Synergistic antimicrobial; Vancomycin.
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