Melatonin attenuates sepsis-induced acute kidney injury by promoting mitophagy through SIRT3-mediated TFAM deacetylation

  • Autophagy. 2023 Aug 31;1-15. doi: 10.1080/15548627.2023.2252265.
Zhiya Deng  1  2 ,  Man He  1  2 ,  Hongbin Hu  1 ,  Wenqian Zhang  1  2 ,  Yaoyuan Zhang  1 ,  Yue Ge  1  3 ,  Tongtong Ma  1 ,  Jie Wu  1 ,  Lulan Li  1 ,  Maomao Sun  1  2 ,  Sheng An  1  2 ,  Jiaxin Li  1 ,  Qiaobing Huang  1  2 ,  Shenhai Gong  1  4 ,  Jiaxing Zhang  1  5 ,  Zhongqing Chen  1 ,  Zhenhua Zeng  1  2
Affiliations
  • 1. Department of Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
  • 2. Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.
  • 3. School of Nursing, Southern Medical University, Guangzhou, Guangdong, China.
  • 4. School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China.
  • 5. The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China.
PMID: 37651673 DOI: 10.1080/15548627.2023.2252265
Abstract

AKI: acute kidney injury; ATP: Adenosine triphosphate; BUN: blood urea nitrogen; CLP: cecal ligation and puncture; eGFR: estimated glomerular filtration rate; H&E: hematoxylin and eosin staining; LCN2/NGAL: lipocalin 2; LPS: lipopolysaccharide; LTL: lotus tetragonolobus lectin; mKeima: mitochondria-targeted Keima; mtDNA: mitochondrial DNA; PAS: periodic acid - Schiff staining; RTECs: renal tubular epithelial cells; SAKI: sepsis-induced acute kidney injury; Scr: serum creatinine; SIRT3: Sirtuin 3; TFAM: transcription factor A, mitochondrial; TMRE: tetramethylrhodamine.

Keywords
Acetylation; acute kidney injury; autophagy; critical care; post-translational modification; sepsis.
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