Transfer of bromocriptine across the blood-brain barrier in man

  • Acta Neurol Scand. 1979 Mar;59(2-3):88-95. doi: 10.1111/j.1600-0404.1979.tb02915.x.
M L Friis ,  O B Paulson ,  M M Hertz
PMID: 377891 DOI: 10.1111/j.1600-0404.1979.tb02915.x
Abstract

The transfer of 14C-bromocriptine across the blood-brain barrier was studied in 10 patients using the double indicator single injection method. The extraction (E) of bromocriptine was 8 % (quartiles: 6 and 14 %). Based on the results the cerebral uptake velocity of bromocriptine was calculated assuming constant arterial drug concentration. Its T 1/2 was found to be 12--24 minutes, depending on the tissue-blood partition coefficient.

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