3D-printed scaffold harboring copper ions combined with near-infrared irradiation for local therapy of cancer

  • iScience. 2023 Sep 27;26(10):108076. doi: 10.1016/j.isci.2023.108076.
Hao Wei  1  2 ,  Dong Chen  3 ,  Bin Han  3 ,  Peng Li  3 ,  Hao Jia  3 ,  Lizhang Zhu  3 ,  Hao Yang  1 ,  Deren Lan  1 ,  Wei Wei  3 ,  Haibo Chen  1 ,  Yongxiang Luo  2 ,  Yongsheng Zhao  1
Affiliations
  • 1. Department of Nuclear Medicine, Peking University Shenzhen Hospital, Shenzhen 518036, China.
  • 2. Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, Department of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen 518055, China.
  • 3. Department of Thyroid and Breast Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, China.
PMID: 37860764 DOI: 10.1016/j.isci.2023.108076
Abstract

Cancer is a major health threat and a leading cause of human death worldwide. Surgical resection is the primary treatment for most cancers; however, some patients develop locoregional recurrence. Here, we developed an in situ Cancer therapeutic system aimed to locally treat Cancer and prevent postoperative recurrence. A functional scaffold, based on alginate/gelatin and crosslinked with copper ions, was fabricated by 3D printing and showed an excellent photothermal effect under near-infrared (NIR) irradiation. The combination of copper ions and NIR effectively killed thyroid Cancer cells and patient-derived organoids, indicating a synergetic and broad-spectrum antitumor effect on thyroid Cancer through the chemo-photothermal therapy. This implantable stent is designed to provide effective treatment in the vicinity of the tumor site and can be degraded without secondary surgery. The copper-loaded hydrogel scaffold may be a potential candidate for local Cancer treatment and pave the way for precise and effective Cancer therapy.

Keywords
Biomaterials; Biomedical Engineering; Cancer; Materials science.
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