Deoxyuridine increases folate-sensitive fragile site expression in human lymphocytes

  • Am J Med Genet. 1987 Jan;26(1):1-5. doi: 10.1002/ajmg.1320260102.
J A Reidy
PMID: 3812550 DOI: 10.1002/ajmg.1320260102
Abstract

Deoxyuridine (dU) increases chromosome breakage at folic acid (FA)-sensitive common fragile sites (mostly 3p14 and 16q23) in human lymphocytes. This dU-related increase can be suppressed by thymidine or FA. These results suggest that the mechanism of fragile site expression in low FA medium involves misincorporation of dU into DNA.

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