Activation of folypolyglutamate synthetase by pteroic acid

  • Can J Biochem Cell Biol. 1985 Jul;63(7):777-9. doi: 10.1139/o85-098.
P J Vickers ,  R Di Cecco ,  Z B Pristupa ,  K G Scrimgeour
PMID: 3840051 DOI: 10.1139/o85-098
Abstract

The glutamylation of methotrexate catalyzed by beef liver folypolyglutamate synthetase (FPGS) is activated by addition of pteroic acid. Pteroic acid causes greater stimulation of FPGS, including glutamylation of tetrahydrofolate, at neutral pH values (i.e., below the pH optimum of 8.4). We have attributed this activation to a conformational change of FPGS induced by pteroic acid.

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