Anti-trypanosomal Lignans Isolated from Salvadoran Peperomia pseudopereskiifolia

  • J Nat Prod. 2024 Apr 26;87(4):1067-1074. doi: 10.1021/acs.jnatprod.4c00022.
Ulises G Castillo  1 ,  Yoshinori Uekusa  2 ,  Takehiro Nishimura  2 ,  Fumiyuki Kiuchi  2 ,  Morena L Martínez  1 ,  Jenny Menjívar  3 ,  Junko Nakajima-Shimada  4 ,  Marvin J Núñez  1 ,  Haruhisa Kikuchi  2
Affiliations
  • 1. Laboratorio de Investigación en Productos Naturales, Facultad de Química y Farmacia, Universidad de El Salvador, Final Avenida de Mártires y Héroes del 30 de Julio, San Salvador 1101, El Salvador.
  • 2. Faculty of Pharmacy, Keio University, 1-5-30, Shibakoen, Minato-ku, Tokyo 105-8512, Japan.
  • 3. Museo de Historia Natural de El Salvador, Ministerio de Cultura, San Salvador 1101, El Salvador.
  • 4. Graduate School of Health Science, Gunma University, 3-39-22 Showamachi, Maebashi, Gunma 371-8514, Japan.
PMID: 38631020 DOI: 10.1021/acs.jnatprod.4c00022
Abstract

A search for anti-trypanosomal natural compounds from Plants collected in El Salvador, a country particularly endemic for Chagas disease, resulted in the isolation of five lignan-type compounds (1-5) from Peperomia pseudopereskiifolia. The lignan derivatives 1, 2, and 4 are new. Their absolute configuration was determined by chemical derivatization. Compounds 1, 5, 6, and 8 exhibited anti-trypanosomal activity against the amastigote form of T. cruzi comparable to that of the existing drug benznidazole.