Bromine/Sulfur-Substituted 9 H-Carbazoles Produced by the Marine-Derived Streptomyces sp. OUCMDZ-5511 upon NaBr Exposure

  • J Nat Prod. 2024 Jul 1. doi: 10.1021/acs.jnatprod.4c00317.
Pengcheng Yan  1 ,  Jibin Liu  2 ,  Kaixuan Li  1 ,  Peipei Liu  1 ,  Ning Li  2  3 ,  Weiming Zhu  1  4
Affiliations
  • 1. Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
  • 2. Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250103, China.
  • 3. Engineering Research Center of Zebrafish Models for Human Diseases and Drug Screening of Shandong Province, Jinan 250103, China.
  • 4. Key Laboratory for Marine Drugs and Bioproducts, Laoshan Laboratory, Qingdao 266237, China.
PMID: 38949068 DOI: 10.1021/acs.jnatprod.4c00317
Abstract

Ten undocumented carbazole derivatives (2-11) along with the reported analogue (1) were isolated from the mangrove-derived Streptomyces sp. OUCMDZ-5511, cultured with NaBr-supplemented liquid medium. Compounds 1-7 are brominated carbazoles, and 8, 10, and 11 feature an additional thiazole or 2,3-dihydro-1,4-oxathiine rings, respectively. Their structures were identified through spectroscopic techniques, computational chemistry, and X-ray crystallography. Notably, compounds 6 and 8 effectively inhibited immune cell migration, indicating anti-inflammatory activity in vivo, potentially via MyD88/NF-κB pathways, as suggested for compound 6.

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