Two new compounds from the roots of Paeonia lactiflora Pall. and their anti-inflammatory effects

  • Nat Prod Res. 2025 Feb 8:1-8. doi: 10.1080/14786419.2025.2462114.
Bo Fu  1 ,  Jin-Ling Zhang  1 ,  Jia-Tong Wu  1 ,  Si-Yi Wang  1 ,  Yi-Qiang Zhang  1 ,  Juan Pan  1 ,  Wei Guan  1 ,  Zhi-Chao Hao  1 ,  Hai-Xue Kuang  1 ,  Qing-Shan Chen  2 ,  Li-Li Zhang  2 ,  Bing-You Yang  1 ,  Yan Liu  1
Affiliations
  • 1. Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Traditional Chinese Medicine (TCM) Biological Genetics (Heilongjiang Province Double First-Class Construction Interdiscipline), Harbin, People's Republic of China.
  • 2. College of Agriculture, Northeast Agricultural University, Harbin, People's Republic of China.
PMID: 39921546 DOI: 10.1080/14786419.2025.2462114
Abstract

Two new compounds (1-2), together with six known ones (3-8), were isolated from the roots of Paeonia lactiflora Pall. The structures of two new compounds were elucidated based on HR-ESI-MS, UV, and NMR spectroscopic data analysis. Moreover, the anti-inflammatory activities of compounds 1-8 were determined using LPS-induced RAW 264.7 cells. Compounds 2, 6, and 8 showed the most potent inhibitory activities on NO production with IC50 values of 17.34 ± 1.5, 27.22 ± 1.3, and 14.79 ± 1.7 μM, respectively. Compounds 4 and 7 showed moderate inhibitory activities. Compounds 3 and 5 showed relatively weak inhibitory activities.

Keywords
Lignan; Paeonia lactiflora Pall; anti-inflammatory; benzofuran.
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