Hedopeptolide, a NO Production Inhibitor from the Marine Cyanobacterium Okeania sp

  • J Nat Prod. 2025 Apr 25;88(4):1023-1029. doi: 10.1021/acs.jnatprod.5c00095.
Shunya Tojo  1 ,  Noriyuki Natsume  1 ,  Taiki Niino  2 ,  Arihiro Iwasaki  3 ,  Kiyotake Suenaga  3 ,  Osamu Ohno  2 ,  Toshiaki Teruya  1  4
Affiliations
  • 1. Graduate School of Engineering and Science, University of the Ryukyus, 1 Senbaru, Nishihara, Okinawa 903-0213, Japan.
  • 2. Department of Chemistry and Life Science, School of Advanced Engineering, Kogakuin University, 2665-1 Nakano-machi, Hachi-oji, Tokyo 192-0015, Japan.
  • 3. Department of Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yoko-hama, Kanagawa 223-8522, Japan.
  • 4. Faculty of Education, University of the Ryukyus, 1 Senbaru, Nishihara, Okinawa 903-0213, Japan.
PMID: 40145845 DOI: 10.1021/acs.jnatprod.5c00095
Abstract

A novel 19-membered cyclic depsipeptide, hedopeptolide (1), was isolated from Okeania sp., a marine cyanobacterium collected in Okinawa, Japan. Its gross structure was determined by spectroscopic analyses, and the absolute configuration of the chiral centers was determined by single-crystal X-ray diffraction analysis following crystallization. Hedopeptolide (1) inhibited the lipopolysaccharide-induced nitric oxide production in RAW264.7 cells.

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