Design, synthesis, and biological evaluation of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-one derivatives as potent hematopoietic progenitor kinase 1 (HPK1) inhibitors

  • Bioorg Chem. 2025 Jul 1:161:108554. doi: 10.1016/j.bioorg.2025.108554.
Yuan Yin  1 ,  Chengqi Wang  1 ,  Huan Liang  1 ,  Yanpeng Ji  1 ,  Damin Zhao  1 ,  Lilong Wang  1 ,  Wei Shi  1 ,  Xiaojin Wang  1 ,  Yong Gao  2 ,  Baomin Liu  3
Affiliations
  • 1. Chia Tai Tianqing Pharmaceutical Group Co., Ltd, Jiangsu Key Laboratory of Antiviral Drug Research, 1099 Fuying Road, Jiangning District, Nanjing, Jiangsu Province, China.
  • 2. Chia Tai Tianqing Pharmaceutical Group Co., Ltd, Jiangsu Key Laboratory of Antiviral Drug Research, 1099 Fuying Road, Jiangning District, Nanjing, Jiangsu Province, China. Electronic address: [email protected].
  • 3. Chia Tai Tianqing Pharmaceutical Group Co., Ltd, Jiangsu Key Laboratory of Antiviral Drug Research, 1099 Fuying Road, Jiangning District, Nanjing, Jiangsu Province, China. Electronic address: [email protected].
PMID: 40347769 DOI: 10.1016/j.bioorg.2025.108554
Keywords
2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-one derivatives; Cancer immunotherapy; HPK1 inhibitors; Immunotherapy.
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