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Cat. No.: HY-172875

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HPK1-IN-58

HPK1-IN-58 (Compound 26) is an inhibitor of HPK1 (IC₅₀: 2.6 nM) and SLP76 (IC₅₀: 20 nM). HPK1-IN-58 enhances IL-2 secretion and reverses PGE2-induced immunosuppression. HPK1-IN-58 can be used in anti-tumor immunity research.

For research use only. We do not sell to patients.

CAS No.: 3093724-62-7
Formula: C₂₆H₃₀N₈O
Molecular Weight:470.57

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

HPK1-IN-58 Chemical Structure

CAS No.: 3093724-62-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Parmacokinetics
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All MAP4K Isoforms :

All Interleukin Related Isoforms :

Parmacokinetics

Species	Dose	Route	AUC	MRT	T_1/2	Bioavailability	T_max	Plasma Concentration
Mice^[1]	1 mg/kg	i.v.	0.424 μg·h/mL	1.90 h	1.50 h	32.08 %	/	/
Mice^[1]	10 mg/kg	i.g.	0.136 μg·h/mL	5.76 h	3.84 h	/	1 h	159 ng/mL

Chemical Information

CAS No. 3093724-62-7
Molecular Weight 470.57
Formula C₂₆H₃₀N₈O
SMILES

CNCC1=NC(N2C(C)(C)CCC2)=CC3=C1CN(C4=NC(C5=NN=C6N5C(C7)C7C6)=CC=C4)C3=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yin Y, et al. Design, synthesis, and biological evaluation of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-one derivatives as potent hematopoietic progenitor kinase 1 (HPK1) inhibitors. Bioorg Chem. 2025 May 1;161:108554. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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Biological Activity
- Description
Chemical Information
Protocols
Purity & Documentation
References

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HPK1-IN-58

All MAP4K Isoforms

All Interleukin Related Isoforms