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Cat. No.: HY-172875

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HPK1-IN-58

HPK1-IN-58 (Compound 26) is an inhibitor of HPK1 (IC₅₀: 2.6 nM) and SLP76 (IC₅₀: 20 nM). HPK1-IN-58 enhances IL-2 secretion and reverses PGE2-induced immunosuppression. HPK1-IN-58 can be used in anti-tumor immunity research.

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CAS No.: 3093724-62-7
Formule: C₂₆H₃₀N₈O
Masse moléculaire:470.57

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

HPK1-IN-58 Chemical Structure

CAS No.: 3093724-62-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Parmacokinetics
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

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Parmacokinetics

Species	Dose	Route	AUC	MRT	T_1/2	Bioavailability	T_max	Plasma Concentration
Mice^[1]	1 mg/kg	i.v.	0.424 μg·h/mL	1.90 h	1.50 h	32.08 %	/	/
Mice^[1]	10 mg/kg	i.g.	0.136 μg·h/mL	5.76 h	3.84 h	/	1 h	159 ng/mL

Chemical Information

CAS No. 3093724-62-7
Masse moléculaire 470.57
Formule C₂₆H₃₀N₈O
SMILES

CNCC1=NC(N2C(C)(C)CCC2)=CC3=C1CN(C4=NC(C5=NN=C6N5C(C7)C7C6)=CC=C4)C3=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Yin Y, et al. Design, synthesis, and biological evaluation of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-one derivatives as potent hematopoietic progenitor kinase 1 (HPK1) inhibitors. Bioorg Chem. 2025 May 1;161:108554. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
Chemical Information
Pureté et documentation
Références

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HPK1-IN-58

Voir tous les produits spécifiques à Isoform MAP4K

Voir tous les produits spécifiques à Isoform Interleukin Related