Effect of post-mating TAK-683 (Kisspeptin analog) treatment on luteal morphology and function in suckling goats with lactational anestrus

  • Anim Reprod Sci. 2026 Jan:284:108052. doi: 10.1016/j.anireprosci.2025.108052.
Gökhan Uyanık  1 ,  Murat Yüksel  2 ,  Murat Abay  3 ,  Ahmet Gözer  4 ,  Ufuk Kaya  5 ,  Filiz Kara  6 ,  Ebru Arslanhan  7 ,  Ishak Gökçek  8
Affiliations
  • 1. Hatay Mustafa Kemal University, Faculty of Veterinary Medicine, Department of Obstetrics and Gynaecology, Antakya, Hatay 31001, Turkiye. Electronic address: [email protected].
  • 2. Hatay Mustafa Kemal University, Faculty of Veterinary Medicine, Department of Obstetrics and Gynaecology, Antakya, Hatay 31001, Turkiye. Electronic address: [email protected].
  • 3. Erciyes University, Faculty of Veterinary Medicine, Department of Obstetrics and Gynaecology, Talas, Kayseri 38280, Turkiye. Electronic address: [email protected].
  • 4. Hatay Mustafa Kemal University, Faculty of Veterinary Medicine, Department of Obstetrics and Gynaecology, Antakya, Hatay 31001, Turkiye. Electronic address: [email protected].
  • 5. Hatay Mustafa Kemal University, Faculty of Veterinary Medicine, Department of Biostatistics, Antakya, Hatay 31001, Türkiye. Electronic address: [email protected].
  • 6. Hatay Mustafa Kemal University, Faculty of Veterinary Medicine, Department of Obstetrics and Gynaecology, Antakya, Hatay 31001, Turkiye. Electronic address: [email protected].
  • 7. Hatay Mustafa Kemal University, Faculty of Veterinary Medicine, Department of Obstetrics and Gynaecology, Antakya, Hatay 31001, Turkiye. Electronic address: [email protected].
  • 8. Hatay Mustafa Kemal University, Faculty of Veterinary Medicine, Department of Physiology, Antakya, Hatay 31001, Turkiye. Electronic address: [email protected].
PMID: 41343946 DOI: 10.1016/j.anireprosci.2025.108052
Abstract

This study aimed to evaluate the effects of TAK-683 administered to suckling goats in lactational anestrus on the 4th day (D4) after mating on luteal function, serum progesterone (P₄) levels, and reproductive performance. Forty-five Aleppo goats were treated with intravaginal sponges containing medroxyprogesterone acetate for 7 days and were injected intramuscularly with 500 IU eCG and 75 µg d-cloprostenol on the day of Sponge removal. Thirty-seven goats showed estrus and were mated with fertile bucks (D0). The mated goats were randomly divided into groups to receive subcutaneous administration of saline (Control, n = 12), 5 μg TAK-683 (TAK-5, n = 12) or 25 μg TAK-683 (TAK-25, n = 13) on D4. Transrectal ovarian ultrasonography and blood sampling were performed on D4, D7, D14, D17, and D21, and pregnancy was diagnosed on D35. Regardless of dose, TAK-683 treatment induced the formation of accessory corpora lutea (aCL) and significantly increased original CL (oCL) diameter, luteal area (LA), and Doppler area (DA) compared with controls (P < 0.001). Total LA and DA were greater (P < 0.001) in TAK-5 and TAK-25, although DA/LA ratio did not differ (P > 0.05). Serum P₄ levels were significantly higher in TAK-25 from D7 to D21 (P < 0.001), while TAK-5 showed a delayed increase from D17. Luteal morphological parameters were strongly and positively correlated with circulating P₄ levels, confirming the luteotropic effect of TAK-683. TAK-683 treatment had no significant effect on fertility parameters (P < 0.05). In conclusion, although TAK-683 treatment enhanced luteal function and increased circulating P₄ concentrations, it failed to improve fertility outcomes in suckling goats under lactational anestrus conditions.

Keywords
Corpus luteum; Dairy goats; Kisspeptin; Progesterone; TAK-683.
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