SIRT2 Inhibition promotes microglia LC3-associated phagocytosis via NRF2/CD36 after the experimental subarachnoid hemorrhage

  • J Neuroinflammation. 2025 Dec 12. doi: 10.1186/s12974-025-03623-z.
Bin Sheng  #  1  2  3  4 ,  Xiangxin Chen  #  3 ,  Tao Tao  #  3 ,  Jiaqing Sun  #  3 ,  Wei Li  3 ,  Lingyun Wu  3 ,  Zheng Peng  3 ,  Xiaojian Li  3 ,  Zhengxu Zhou  3 ,  Qian Yu  2 ,  Yeping Ling  2 ,  Prativa Sherchan  2 ,  Jerry J Flores  2 ,  Jiping Tang  2 ,  Lei Huang  5  6 ,  Chunhua Hang  7 ,  John H Zhang  8  9
Affiliations
  • 1. Department of Neurosurgery, The First Affiliated Hospital of Wannan Medical College, (Yijishan Hospital of Wannan Medical College), The Translational Research Institute for Neurological Disorders of Wannan Medical College, Wuhu, China.
  • 2. Department of Physiology and Pharmacology, Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, CA, 92354, USA.
  • 3. Department of Neurosurgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Neurosurgical Institute of Nanjing University, Nanjing, China.
  • 4. Department of Neurosurgery, Loma Linda University School of Medicine, Loma Linda, CA, 92354, USA.
  • 5. Department of Physiology and Pharmacology, Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, CA, 92354, USA. [email protected].
  • 6. Department of Neurosurgery, Loma Linda University School of Medicine, Loma Linda, CA, 92354, USA. [email protected].
  • 7. Department of Neurosurgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Neurosurgical Institute of Nanjing University, Nanjing, China. [email protected].
  • 8. Department of Physiology and Pharmacology, Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, CA, 92354, USA. [email protected].
  • 9. Department of Neurosurgery, Loma Linda University School of Medicine, Loma Linda, CA, 92354, USA. [email protected].
  • # Contributed equally.
PMID: 41388303 DOI: 10.1186/s12974-025-03623-z
Keywords
LAP; Microglia; Phagocytosis; SIRT2; Subarachnoid hemorrhage.
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