A heavy-chain antibody-drug conjugate targeting glycosylated CEACAM6 inhibits brain metastatic tumor growth PMID: 41912133

ADC Targets in Oncology

2026-04-10

A heavy-chain antibody-drug conjugate targeting glycosylated CEACAM6 inhibits brain metastatic tumor growth

Cancer Lett. 2026 Jun 28:648:218463. doi: 10.1016/j.canlet.2026.218463.

Yao-Tsung Tsai ¹ , Min-Hsuan Yen ² , Ping-Jen Hu ³ , Cheng-Chung Lee ⁴ , Chang-Yi Liu ⁵ , Tsai-Mu Cheng ⁴ , Hsieh-Tsung Shen ⁶ , Bo-Xiang Benjamin Zhang ⁷ , Hsin-Lun Lee ⁸ , Kuo-Hsiang Chuang ⁹ , Chee-Voon Yap ¹⁰ , Wen-Chang Wang ¹ , Ming-Heng Wu ¹¹

Affiliations

1. International Ph.D. Program for Translational Science, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan; The Ph.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan; International Master Program for Translational Science, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan; TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei, Taiwan.
2. Division of Colorectal Surgery, Department of Surgery, Taipei Medical University Shuang-Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.
3. Division of Gastroenterology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
4. International Ph.D. Program for Translational Science, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan; The Ph.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan; International Master Program for Translational Science, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.
5. Ji Yan Biomedical (JY BioMed) Co., Ltd, Taipei, Taiwan.
6. Ji Yan Biomedical (JY BioMed) Co., Ltd, Taipei, Taiwan; Division of Clinical Cariology and Endodontology, Department of Oral Rehabilitation, School of Dentistry, Health Sciences University of Hokkaido, Hokkaido, Japan.
7. Ji Yan Biomedical (JY BioMed) Co., Ltd, Taipei, Taiwan; Division of Clinical Cariology and Endodontology, Department of Oral Rehabilitation, School of Dentistry, Health Sciences University of Hokkaido, Hokkaido, Japan; Ph.D. Program in Medical Neuroscience, College of Medical Science and Technology, Taipei Medical University and National Health Research Institutes, Taiwan.
8. Department of Radiation Oncology, Taipei Medical University Hospital, Taipei, Taiwan; Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
9. The Ph.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan; Graduate Institute of Pharmacognosy, Taipei Medical University, Taipei, Taiwan.
10. International Ph.D. Program for Translational Science, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.
11. International Ph.D. Program for Translational Science, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan; The Ph.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan; International Master Program for Translational Science, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan; TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address: [email protected].