Mixed Monolayer Characteristics of Tangeretin with Stearic Acid and Dipalmitoyl Phosphatidyl Choline at the Air/Water Interface

  • Molecules. 2026 Jun 4;31(11):1952. doi: 10.3390/molecules31111952.
Yawen Zhou  1 ,  Wanqing Wang  1 ,  Tianqi Jia  1 ,  Yifan Zhang  1 ,  Nan Wang  1 ,  Baocai Xu  1
Affiliations
  • 1. School of Light Industry Science and Engineering, Beijing Technology and Business University, No. 33 Fucheng Road, Beijing 100048, China.
PMID: 42280254 DOI: 10.3390/molecules31111952
Abstract

As a natural compound with various biological activities, tangeretin (TAN) has numerous potential advantages in food and medical fields. However, its poor aqueous solubility and bioavailability limit its effective application. In this paper, the mixed monolayer characteristics of different mass fractions of TAN with stearic acid (SA) and dipalmitoyl phosphatidyl choline (DPPC) were investigated. The optimal film-forming composition was obtained by analyzing the molecular area, monolayer compressibility, shrinkage and expansion, and Other thermodynamic parameters. The results indicated that there was mutual repulsion between SA and TAN molecules, and the stability of the monolayer was poor. However, TAN/DPPC mixed monolayers exhibited favorable interactions and mutual attraction between the two components. When ωTAN was 0.2, the minimum excess surface pressure of the TAN/DPPC system was -17.16 mN/m, and the minimum excess Helmholtz free energy was -3413.62 J/mol. At this composition, the intermolecular attraction between DPPC and TAN was strongest, and the mixed monolayer displayed strong deformation resistance and high stability.

Keywords
Langmuir monolayers; dipalmitoyl phosphatidyl choline; stearic acid; tangeretin.
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