AHR-6646: a new, long-acting neuroleptic

  • Prog Neuropsychopharmacol. 1979;3(5-6):513-20. doi: 10.1016/0364-7722(79)90005-5.
D N Johnson  1 ,  B G Turley ,  M R Jones ,  C B Coffin ,  C A Leonard ,  W H Funderburk
Affiliations
  • 1. A. H. Robins Research Laboratories, Richmond, VA.
PMID: 45570 DOI: 10.1016/0364-7722(79)90005-5
Abstract

1. AHR-6646 blocked d-amphetamine lethality in mice under aggregated conditions when the pretreatment interval was between one hour and seven days. 2. Conditioned avoidance responding in mice and cats was suppressed by AHR-6646 in doses that did not impair escape behavior. The duration of this effect was markedly prolonged. 3. AHR-6646 produced catalepsy in rats. The onset of this effect was delayed and the duration was prolonged when compared with that of chlorpromazine. 4. Apomorphine-induced pivoting in mice with unilateral lesions of the caudate nucleus was suppressed by AHR-6646. 5. AHR-6646 was a potent antiemetic agent in dogs, with a delayed onset and prolonged duration of action.

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