Double bond isomers of cloprostenol

  • Prostaglandins. 1979 Jun;17(6):789-800. doi: 10.1016/0090-6980(79)90053-4.
J Bowler ,  E D Brown ,  N S Crossley ,  D W Heaton ,  T J Lilley ,  N Rose
PMID: 504688 DOI: 10.1016/0090-6980(79)90053-4
Abstract

The syntheses of five compounds isomeric with the potent luteolytic agent cloprostenol are described. These are the trans-delta 5, cis and trans-delta 4, cis-delta 6 (methyl ester) and cis-delta 13 analogues. The cis-delta 4 isomer is as potent as cloprostenol as a luteolytic agent in hamsters but the Others are markedly less so.

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