Activity of ketoconazole and its deacyl derivative against Plasmodium falciparum and Candida isolates

  • Antimicrob Agents Chemother. 1982 Nov;22(5):917-9. doi: 10.1128/AAC.22.5.917.
M A Pfaller ,  J J Segal ,  D J Krogstad
PMID: 6295271 DOI: 10.1128/AAC.22.5.917
Abstract

Deacylketoconazole was 15- to 50-fold more active against Plasmodium falciparum than was ketoconazole, based on [(3)H]hypoxanthine uptake and quantitative Parasite counts. In contrast, there were no significant differences between these drugs in their activity against clinical isolates of Candida spp.

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