Studies on WF-3161, a new antitumor antibiotic

  • J Antibiot (Tokyo). 1983 May;36(5):478-83. doi: 10.7164/antibiotics.36.478.
K Umehara ,  K Nakahara ,  S Kiyoto ,  M Iwami ,  M Okamoto ,  H Tanaka ,  M Kohsaka ,  H Aoki ,  H Imanaka
PMID: 6860430 DOI: 10.7164/antibiotics.36.478
Abstract

WF-3161 is an antitumor Antibiotic produced by a strain of fungus, Petriella guttulata. The Antibiotic was purified by solvent extraction and a combination of silica gel and reverse phase column chromatography. The chemical structure of the Antibiotic (C31H44N4O6, mp 181-183 degrees C) was found to be a cyclic tetrapeptide consisting of phenylalanine, leucine, pipecolinic acid and 2-amino-8-oxo-9,10-epoxydecanoic acid. WF-3161 inhibited the growth of Trichophyton asteroides. It prolonged survival period of mice bearing leukemia P-388 with a high therapeutic index.

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