A new anti-mycotic drug tioxaprofen and its uncoupling effect on isolated mitochondria

  • Experientia. 1983 Aug 15;39(8):889-90. doi: 10.1007/BF01990422.
K Kawai ,  R Watanabe ,  Y Nozawa ,  M Nozaki ,  K Tsurumi ,  H Fujimura
PMID: 6873243 DOI: 10.1007/BF01990422
Abstract

An oxazole compound, tioxaprofen, exerted a strong anti-mycotic activity against Trichophyton mentagrophytes and T. rubrum, which were major dermatophytes from patients. It was found that tioxaprofen was a potent uncoupling agent of mitochondrial respiration.

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