Vanoxonin, a new inhibitor of thymidylate synthetase

  • J Antibiot (Tokyo). 1983 Jun;36(6):656-60. doi: 10.7164/antibiotics.36.656.
F Kanai ,  T Sawa ,  M Hamada ,  H Naganawa ,  T Takeuchi ,  H Umezawa
PMID: 6874588 DOI: 10.7164/antibiotics.36.656
Abstract

Vanoxonin, a new inhibitor of thymidylate synthetase, was found in cultured broths of the strain MG245-CF2 classified as Saccharopolyspora hirsuta. Vanoxonin, C18H25N3O9, was obtained as colorless powder. Vanoxonin forms a vanadium complex which exhibits a strong inhibition against thymidylate synthetase. The concentration for 50% inhibition of the enzyme (IC50) was 0.7 micrograms/ml.

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