[Tetragastrin activation of rat gastric mucosa adenyl cyclase in vitro]

The effect of tetragastrin and histamine on the Adenylate Cyclase activity of the rat gastric mucosa was examined in vitro. Tetragastrin and histamine were demonstrated to stimulate the activity of the enzyme in question. The antagonist of histamine H2-receptors, cimetidine inhibits the stimulatory effect of histamine in vitro and activates tetragastrin stimulation of the Adenylate Cyclase activity. It is suggested that tetragastrin and histamine activate Adenylate Cyclase of the rat gastric mucosa via different receptors.