The isolation and structural elucidation of three new neolignans, piperulins [corrected] A, B, and C, as platelet activating factor receptor antagonists from Piper puberulum

  • J Nat Prod. 1995 Apr;58(4):540-7. doi: 10.1021/np50118a009.
S X Zhang  1 ,  K Chen ,  X J Liu ,  D C Zhang ,  T W Tao-Wiedmann ,  S L Leu ,  A T McPhail ,  K H Lee
Affiliations
  • 1. Natural Products Laboratory, School of Pharmacy, University of North Carolina, Chapel Hill 27599, USA.
PMID: 7623032 DOI: 10.1021/np50118a009
Abstract

Three new neolignans, piperulins [corrected] A [1], B [2], and C [3], were isolated from Piper puberulum. Their structures and relative stereochemistries were determined from spectral data and the X-ray crystallographic analysis of 1. Compounds 1 and 3 inhibit specific platelet activating factor receptor binding with IC50 values of 7.3 and 5.7 microM, respectively.

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