Usnic acid and diffractaic acid as analgesic and antipyretic components of Usnea diffracta

  • Planta Med. 1995 Apr;61(2):113-5. doi: 10.1055/s-2006-958027.
E Okuyama  1 ,  K Umeyama ,  M Yamazaki ,  Y Kinoshita ,  Y Yamamoto
Affiliations
  • 1. Faculty of Pharmaceutical Sciences, Chiba University, Japan.
PMID: 7753915 DOI: 10.1055/s-2006-958027
Abstract

Diffractaic acid and usnic acid were identified as the analgesic and antipyretic components of a Lichen, Usnea diffracta. Both compounds showed an analgesic effect by the acetic acid-induced writhing and tail-pressure methods in mice. Regarding the effect on normal body temperature and LPS-induced hyperthermia in mice, diffractaic acid showed a significant effect only on the former and usnic acid only on the latter.

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