Chaetomella acutiseta produces chaetomellic acids A and B which are reversible inhibitors of farnesyl-protein transferase

  • Appl Microbiol Biotechnol. 1993 Nov;40(2-3):370-4. doi: 10.1007/BF00170395.
R B Lingham  1 ,  K C Silverman ,  G F Bills ,  C Cascales ,  M Sanchez ,  R G Jenkins ,  S E Gartner ,  I Martin ,  M T Diez ,  F Peláez
Affiliations
  • 1. Merck Research Laboratories, Rahway, NJ 07065.
PMID: 7764394 DOI: 10.1007/BF00170395
Abstract

Chaetomellic acids A and B, isolated from Chaetomella acutiseta, are specific inhibitors of farnesyl-protein transferase that do not inhibit geranylgeranyl transferase type 1 or squalene synthase. Chaetomellic acids A and B are reversible inhibitors, resemble farnesyl diphosphate and probably inhibit FPTase by substituting for farnesyl diphosphate. Chaetomellic acid production appears to be widespread within the genus Chaetomella.

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