Berninamycins B, C, and D, minor metabolites from Streptomyces bernensis

  • J Antibiot (Tokyo). 1994 Dec;47(12):1466-72. doi: 10.7164/antibiotics.47.1466.
R C Lau  1 ,  K L Rinehart
Affiliations
  • 1. Roger Adams Laboratory, University of Illinois, Urbana 61801.
PMID: 7844041 DOI: 10.7164/antibiotics.47.1466
Abstract

Berninamycins B, C, and D were isolated from fermentation of Streptomyces bernensis and their structures were studied with 13C NMR and FAB mass spectrometry. Berninamycin B has a valine unit in its cyclic peptide loop instead of the beta-hydroxyvaline unit found in berninamycin A. Berninamycin D has two fewer dehydroalanine units attached to the carboxyl carbon of the pyridine ring. Based on FAB-MS results, berninamycin C is postulated to have only one dehydroalanine unit attached to the carboxyl carbon of pyridine. The biogenesis of berninamycins B, C, and D is discussed.

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