Bacithrocins A, B and C, novel thrombin inhibitors

  • J Antibiot (Tokyo). 1994 Sep;47(9):959-68. doi: 10.7164/antibiotics.47.959.
T Kamiyama  1 ,  T Umino ,  Y Nakamura ,  Y Itezono ,  S Sawairi ,  T Satoh ,  K Yokose
Affiliations
  • 1. Nippon Roche Research Center, Kanagawa, Japan.
PMID: 7928697 DOI: 10.7164/antibiotics.47.959
Abstract

Novel Thrombin inhibitors, bacithrocins A, B and C, have been isolated from the culture broth of Bacillus laterosporus Laubach NR 2988. The structures of these inhibitors have been determined to be N-acyl-L-phenylalanyl-DL-arginal by the 2D-NMR experiments on their oxidation products and by amino acid analysis. Bacithrocin A inhibits Thrombin, Factor Xa and trypsin with IC50s of 48, 13 and 0.65 microM, respectively, which are similar to those of bacithrocins B and C. Bacithrocins prolong the clotting time induced by Thrombin and Factor Xa.

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