Isokotanins A-C: new bicoumarins from the sclerotia of Aspergillus alliaceus

  • J Nat Prod. 1994 Jan;57(1):128-33. doi: 10.1021/np50103a018.
J A Laakso  1 ,  E D Narske ,  J B Gloer ,  D T Wicklow ,  P F Dowd
Affiliations
  • 1. Department of Chemistry, University of Iowa, Iowa City, 52242.
PMID: 8158157 DOI: 10.1021/np50103a018
Abstract

Three new bicoumarin metabolites, isokotanins A [1], B [2], and C [3], were isolated from the sclerotia of Aspergillus alliaceus. Isokotanin A is a regioisomer of the known bicoumarin kotanin [4]. The structures and spectral assignments for 1-3 were determined on the basis of selective INEPT, HMQC, and NOESY nmr data, as well as by chemical interconversions. Isokotanins B and C show activity against the corn earworm Helicoverpa zea and the dried fruit bettle Carpophilus hemipterus. The known compounds kotanin [4], desmethylkotanin [5], nominine, and paspaline were also isolated from extracts of A. alliaceus sclerotia.

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