Manumycins E, F and G, new members of manumycin class antibiotics, from Streptomyces sp

  • J Antibiot (Tokyo). 1994 Mar;47(3):324-33. doi: 10.7164/antibiotics.47.324.
Y Z Shu  1 ,  S Huang ,  R R Wang ,  K S Lam ,  S E Klohr ,  K J Volk ,  D M Pirnik ,  J S Wells ,  P B Fernandes ,  P S Patel
Affiliations
  • 1. Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, CT 06492.
PMID: 8175485 DOI: 10.7164/antibiotics.47.324
Abstract

Three new manumycin class Antibiotics, namely manumycins E, F and G, were isolated from the culture broth of Streptomyces sp. strain WB-8376. Their structures were established by spectroscopic methods, and the S configuration of C-4 in the epoxycyclohexenone moiety was determined by CD exciton chirality method for each of the three compounds. Manumycins E, F and G are active against Gram-positive bacteria, and have moderate inhibitory effects on the farnesylation of p21 Ras protein. They demonstrated weak cytotoxic activity against human colon tumor cell HCT-116.

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