Plant antitumor agents. 31. The calycopterones, a new class of biflavonoids with novel cytotoxicity in a diverse panel of human tumor cell lines

  • J Med Chem. 1994 May 13;37(10):1465-70. doi: 10.1021/jm00036a012.
M E Wall  1 ,  M C Wani ,  F Fullas ,  J B Oswald ,  D M Brown ,  T Santisuk ,  V Reutrakul ,  A T McPhail ,  N R Farnsworth ,  J M Pezzuto
Affiliations
  • 1. Research Triangle Institute, Research Triangle Park, North Carolina 27709.
PMID: 8182705 DOI: 10.1021/jm00036a012
Abstract

Three new biflavonoids to which we have accorded the trivial names calycopterone (1), isocalycopterone (2), and 4-demethylcalycopterone (3) and the known flavone 4',5-dihydroxy-3,3',6,7-tetramethoxyflavone (4) were isolated as cytotoxic constituents from the flowers of Calycopteris floribunda Lamk. (Combretaceae). Compounds 1-3 showed a wide range of activity against a panel of solid tumor cell lines. Among the biflavonoids, calycopterone (1) is the major constituent.