Aquastatin A, an inhibitor of mammalian adenosine triphosphatases from Fusarium aquaeductuum. Taxonomy, fermentation, isolation, structure determination and biological properties

  • J Antibiot (Tokyo). 1993 Nov;46(11):1648-57. doi: 10.7164/antibiotics.46.1648.
K Hamano  1 ,  M Kinoshita-Okami ,  K Minagawa ,  H Haruyama ,  T Kinoshita ,  T Hosoya ,  K Furuya ,  K Kinoshita ,  K Tabata ,  A Hemmi, et al.
Affiliations
  • 1. Fermentation Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan.
PMID: 8270486 DOI: 10.7164/antibiotics.46.1648
Abstract

A new inhibitor of mammalian adenosine triphosphatases, designated aquastatin A, has been isolated from a fungus identified as Fusarium aquaeductuum. The structure of this compound has been determined by MS and NMR analyses. It inhibits Na+/K(+)-ATPase with an IC50 value of 7.1 microM, and H+/K(+)-ATPase with an apparent IC50 value of 6.2 microM.

Products