Steroids 51. An improved synthesis of ORG 2058 and the synthesis of [3H]ORG 2058

  • Steroids. 1993 Mar;58(3):115-8. doi: 10.1016/0039-128x(93)90047-q.
T Bakos  1 ,  M Lökös ,  I Vincze ,  J Volford
Affiliations
  • 1. Department of Organic Chemistry, Attila József University, Szeged, Hungary.
PMID: 8475515 DOI: 10.1016/0039-128x(93)90047-q
Abstract

16 alpha-Ethyl-21-hydroxy-19-norpregn-4-ene-3,20-dione (ORG 2058) is a ligand widely used in Progesterone Receptor assays. An improved synthesis of the compound is reported, starting from norethisterone acetate. The preparation of the tritiated radioligand [3H]ORG 2058 is also described.

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