Tonkinecin, a novel bioactive annonaceous acetogenin from Uvaria tonkinesis

  • J Nat Prod. 1996 May;59(5):507-9. doi: 10.1021/np960321h.
Y Chen  1 ,  D Q Yu
Affiliations
  • 1. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
PMID: 8778240 DOI: 10.1021/np960321h
Abstract

A novel bioactive monotetrahydrofuran acetogenin named tonkinecin (1) and two known compounds, uvariamicins I and II, have been isolated from the roots of Uvaria tonkinesis. The structure of 1 was elucidated using spectral methods and its absolute stereochemistry established by 1H-NMR experiments utilizing Mosher ester methodology.