Bafilomycin A1 and intracellular multiplication of Legionella pneumophila

  • Antimicrob Agents Chemother. 1997 Jan;41(1):212-4. doi: 10.1128/AAC.41.1.212.
L Cattani  1 ,  P Goldoni ,  M C Pastoris ,  L Sinibaldi ,  N Orsi
Affiliations
  • 1. Istituto di Microbiologia, Facoltà di Medicina e Chirurgia, Università La Sapienza, Rome, Italy.
PMID: 8980784 DOI: 10.1128/AAC.41.1.212
Abstract

Multiplication of Legionella pneumophila in HeLa cells was found to be inhibited by noncytotoxic concentrations of bafilomycin A1, with blockage of Bacterial growth at a concentration 15.6 nM. The inhibiting action was evident only when the Antibiotic was present during the initial phase of intracellular multiplication, i.e., during the formation of the phagosome, whereas the addition of the drug did not affect Microorganisms already actively multiplying within the phagosome.

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