Epoxyquinomicins A, B, C and D, new antibiotics from Amycolatopsis. I. Taxonomy, fermentation, isolation and antimicrobial activities

  • J Antibiot (Tokyo). 1997 Nov;50(11):900-5. doi: 10.7164/antibiotics.50.900.
N Matsumoto  1 ,  T Tsuchida ,  M Umekita ,  N Kinoshita ,  H Iinuma ,  T Sawa ,  M Hamada ,  T Takeuchi
Affiliations
  • 1. Institute of Microbial Chemistry, Tokyo, Japan.
PMID: 9592560 DOI: 10.7164/antibiotics.50.900
Abstract

A new structural class of the Antibiotic, epoxyquinomicins A, B, C and D were isolated from the culture broth of the strain MK299-95F4, which was related to Amycolatopsis sulphurea. Antimicrobial activity of epoxyquinomicins A and B were weak against Gram-positive bacteria, and epoxyquinomicins C and D showed almost no antimicrobial activity and no cytotoxicity. All these Antibiotics showed improvement of Collagen induced arthritis in vivo.

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