New iridoids from the medicinal plant Barleria prionitis with potent activity against respiratory syncytial virus

  • J Nat Prod. 1998 Oct;61(10):1295-7. doi: 10.1021/np980086y.
J L Chen  1 ,  P Blanc ,  C A Stoddart ,  M Bogan ,  E J Rozhon ,  N Parkinson ,  Z Ye ,  R Cooper ,  M Balick ,  W Nanakorn ,  M R Kernan
Affiliations
  • 1. Shaman Pharmaceuticals, Inc., 213 East Grand Avenue, South San Francisco, California 94080, USA.
PMID: 9784173 DOI: 10.1021/np980086y
Abstract

Two new iridoid glycosides (1 and 2), together with the known compounds barlerin (3) and verbascoside (4), were isolated from Barleria prionitis. The new iridoid glycosides were determined to be 6-O-trans-p-coumaroyl-8-O-acetylshanzhiside methyl ester (1) and its cis isomer (2) by using spectroscopic, especially 2D NMR, data. A 3:1 mixture of 1 and 2 was shown to have potent in vitro activity against respiratory syncytial virus (EC50 2.46 microgram/mL, IC50 42.2 microgram/mL).