Antitumor activity of paclitaxel and epirubicin in human breast carcinoma, R-27

  • Folia Microbiol (Praha). 1998;43(5):473-4. doi: 10.1007/BF02820793.
F Asanuma  1 ,  Y Yamada ,  E Kawamura ,  K Lee ,  H Kobayashi ,  T Yamada ,  T Suzuki ,  T Kubota
Affiliations
  • 1. Department of Surgery, Kitasato Institute Hospital, Tokyo, Japan.
PMID: 9821299 DOI: 10.1007/BF02820793
Abstract

The antitumor effect of paclitaxel, epirubicin, and both in combination was tested using R-27, an estrogen receptor-positive human breast carcinoma. In an in vivo study using nude mice both drugs showed an additive effect, whereas they showed a supraadditive pattern in in vitro MTT assay. The combination of paclitaxel and epirubicin may enhance the antitumor effect on breast carcinoma.

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