Anti-malarial activities of acylated bruceolide derivatives

  • Bioorg Med Chem Lett. 1998 Mar 3;8(5):459-62. doi: 10.1016/s0960-894x(98)00045-6.
N Murakami  1 ,  T Umezome ,  T Mahmud ,  M Sugimoto ,  M Kobayashi ,  Y Wataya ,  H S Kim
Affiliations
  • 1. Faculty of Pharmaceutical Sciences, Osaka University, Japan.
PMID: 9871598 DOI: 10.1016/s0960-894x(98)00045-6
Abstract

Several O-acylated derivatives of bruceolide (2) were synthesized and their anti-malarial activities together with selective toxicities were examined. It was found that 3,15-di-O-acetyl-(3c), 3,15-di-O-propionyl-(3d) and 15-O-propionylbruceolide (3b), as well as bruceine B (3a), exhibited potent anti-malarial activities with high selective toxicities.