L-tryptophan urea amides as NK1/NK2 dual antagonists

  • Bioorg Med Chem Lett. 1998 Aug 18;8(16):2259-62. doi: 10.1016/s0960-894x(98)00395-3.
H Qi  1 ,  S K Shah ,  M A Cascieri ,  S J Sadowski ,  M MaCcoss
Affiliations
  • 1. Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, New Jersey 07065, USA.
PMID: 9873524 DOI: 10.1016/s0960-894x(98)00395-3
Abstract

We report that a systematic modification of an NK1 receptor selective antagonist resulted in the identification of novel compounds, 4c and 4d, with high affinity for both NK1 and NK2 receptors.