Thalidomide analogs and PDE4 inhibition

  • Bioorg Med Chem Lett. 1998 Oct 6;8(19):2669-74. doi: 10.1016/s0960-894x(98)00475-2.
G W Muller  1 ,  M G Shire ,  L M Wong ,  L G Corral ,  R T Patterson ,  Y Chen ,  D I Stirling
Affiliations
  • 1. Celgene Corporation, Warren, NJ 07059 USA.
PMID: 9873600 DOI: 10.1016/s0960-894x(98)00475-2
Abstract

N-Phthaloyl 3-amino-3-arylpropionic acid analogs of thalidomide that are potent inhibitors of tumor necrosis factor-alpha are reported. These compounds were found to be potent inhibitors of phosphodiesterase 4.